Fetuin-A/AHSG active protein
Human Fetuin-A/AHSG
NCBI and Uniprot Product Information
NCBI Description
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
Subunit structure: Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond.
Subcellular location: Secreted.
Tissue specificity: Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins.
Post-translational modification: Phosphorylation sites are present in the extracellular medium.O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4; N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor). Ref.17 Ref.25 Ref.28
Polymorphism: There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256.
Sequence similarities: Belongs to the fetuin family.Contains 2 cystatin fetuin-A-type domains.
Research Articles on Fetuin-A/AHSG
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Product Notes
The Fetuin-A/AHSG ahsg (Catalog #AAA691955) is an Active Protein produced from HEK 293 Cells and is intended for research purposes only. The product is available for immediate purchase. The Human Fetuin-A/AHSG reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: APHGPGLIYR QPNCDDPETE EAALVAIDYI NQNLPWGYKH TLNQID EVKV WPQQPSGELF EIEIDTLETT CHVLDPTPVA RCSVRQLKEH A VEGDCDFQL LKLDGKFSVV YAKCDSSPDS AEDVRKVCQD CPLLAPL NDT RVVHAAKAAL AAFNAQNNGS NFQLEEISRA QLVPLPPSTY VE FTVSGTDC VAKEATEAAK CNLLAEKQYG FCKATLSEKL GGAEVAVT CT VFQTQPVTSQ PQPEGANEAV PTPVVDPDAP PSPPLGAPGL PPA GSPPDSH VLTVVQPSVG AAAGPVVPPC PGRIRHFKV. It is sometimes possible for the material contained within the vial of "Fetuin-A/AHSG, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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