DLL-1, soluble Active Protein | DLL-1 active protein

Human DLL-1, soluble

Cat. Num. AAA692170

• Gene Names: DLL1; DL1; Delta; DELTA1
• Reactivity: Human
• Purity: > 95%, by SDS-PAGE and HPLC analysis
• Synonyms: DLL-1; soluble; Human DLL-1; Recombinant Human sDLL-1; DLL-1 active protein

• Host: HEK 293 Cells
• Reactivity: Human
• Purity/Purification: > 95%, by SDS-PAGE and HPLC analysis
• Form/Format: Lyophilized
• Sequence: SGVFELKLQE FVNKKGLLGN RNCCRGGAGP PPCACRTFFR VCLKHY QASV SPEPPCTYGS AVTPVLGVDS FSLPDGGGAD SAFSNPIRFP F GFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLATQR HLTVGEE WSQ DLHSSGRTDL KYSYRFVCDE HYYGEGCSVF CRPRDDAFGH FT CGERGEKV CNPGWKGPYC TEPICLPGCD EQHGFCDKPG ECKCRVGW QG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTH HKPCKNG ATCTNTGQGS YTCSCRPGYT GATCELGIDE CDPSPCKNG G SCTDLENSYS CTCPPGFYGK ICELSAMTCA DGPCFNGGRC SDSP DGGYSC RCPVGYSGFN CEKKIDYCSS SPCSNGAKCV DLGDAYLCRC QAGFSGRHCD DNVDDCASSP CANGGTCRDG VNDFSCTCPP GYTGR NCSAP VSRCEHAPCH NGATCHERGH RYVCECARGY GGPNCQFLLP ELPPGPAVVD LTEKLEGQGG PF
• Sequence Length: 723

• Endotoxin Level: < 0.1 ng per ug of sDLL-1
• Biological Activity: Determined by the dose dependent growth suppression of the human acute monocytic leukemia cell line, THP-1. sDLL-1 inhibits the proliferation in THP-1 cells using a concentration of 3.0-5.0 ug/ml.

Related Product Information for DLL-1 active protein

Human sDLL-1 comprises the extracellular signaling domain of DLL1, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. DLL-1 functions to specifically activate the Notch-1 and Notch-2 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. DLL-1 suppresses differentiation of hematopoietic progenitor cells into the B-cell lineage while promoting differentiation to T-cell and NK cell precursors. Recombinant human sDLL-1 is a 57-60 kDa glycoprotein containing 522 amino-acid residues.

Product Categories/Family for DLL-1 active protein

Soluble receptors

NCBI and Uniprot Product Information

• NCBI GI #: 110735443
• NCBI GeneID: 28514
• NCBI Accession #: NP_005609.3
• NCBI GenBank Nucleotide #: NM_005618.3
• UniProt Accession #: O00548; Q9NU41; Q9UJV2; B2RAK7
• Molecular Weight: 57-60 kDa
• NCBI Official Full Name: delta-like protein 1
• NCBI Official Synonym Full Names: delta-like 1 (Drosophila)
• NCBI Official Symbol: DLL1
• NCBI Official Synonym Symbols: DL1; Delta; DELTA1
• NCBI Protein Information: delta-like protein 1; H-Delta-1; drosophila Delta homolog 1
• UniProt Protein Name: Delta-like protein 1
• UniProt Gene Name: DLL1
• UniProt Synonym Gene Names: Delta1; H-Delta-1
• UniProt Entry Name: DLL1_HUMAN

NCBI Description

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Ref.8

Subunit structure: Interacts with Notch receptors.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Post-translational modification: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation

By similarity.

Sequence similarities: Contains 1 DSL domain.Contains 8 EGF-like domains.