BMP-6 active protein

Human BMP-6

Cat. Num. AAA692178

• Gene Names: BMP6; VGR; VGR1
• Reactivity: Human
• Purity: >95% by SDS-PAGE and HPLC analysis
• Synonyms: BMP-6; Human BMP-6; Recombinant Human BMP-6; BMP-6 active protein

• Host: HEK 293 Cells
• Reactivity: Human
• Purity/Purification: >95% by SDS-PAGE and HPLC analysis
• Form/Format: Lyophilized
• Sequence: VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCD GECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI S VLYFDDNSN VILKKYRNMV VRACGCH
• Sequence Length: 513

• Endotoxin Level: < 0.1 ng per ug of BMP-6
• Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 ug/ml.

Related Product Information for BMP-6 active protein

TGF-beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.

Product Categories/Family for BMP-6 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4502425
• NCBI GeneID: 654
• NCBI Accession #: NP_001709.1
• NCBI GenBank Nucleotide #: NM_001718.4
• UniProt Accession #: P22004; Q5TCP3
• Molecular Weight: 26.2 kDa
• NCBI Official Full Name: bone morphogenetic protein 6 preproprotein
• NCBI Official Synonym Full Names: bone morphogenetic protein 6
• NCBI Official Symbol: BMP6
• NCBI Official Synonym Symbols: VGR; VGR1
• NCBI Protein Information: bone morphogenetic protein 6; BMP-6; VGR-1; VG-1-R; VG-1-related protein; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related)
• UniProt Protein Name: Bone morphogenetic protein 6
• UniProt Gene Name: BMP6
• UniProt Synonym Gene Names: VGR; BMP-6; VG-1-R; VGR-1
• UniProt Entry Name: BMP6_HUMAN

NCBI Description

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Induces cartilage and bone formation.

Subunit structure: Interacts with SOSTDC1

By similarity.

Subcellular location: Secreted

By similarity.

Sequence similarities: Belongs to the TGF-beta family.