Rat heart and neural crest derivatives expressed 2 ELISA Kit | HAND2 elisa kit
Rat Heart- and neural crest derivatives-expressed protein 2, HAND2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
acts in complex with Gata4 to activate transcription of cardiac specific genes [RGD, Feb 2006]
Uniprot Description
HAND2: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 4q33
Cellular Component: transcription factor complex; protein complex; nuclear chromatin
Molecular Function: protein binding; protein homodimerization activity; transcription activator binding; AT DNA binding; protein heterodimerization activity; transcription coactivator activity; transcription factor binding
Biological Process: heart morphogenesis; adult heart development; tongue development; transcription, DNA-dependent; thymus development; neural crest cell development; in utero embryonic development; apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; heart development; mesenchymal cell proliferation; palate development; negative regulation of DNA binding; odontogenesis of dentine-containing teeth; peripheral nervous system neuron development; sympathetic nervous system development; suckling behavior; regulation of transcription, DNA-dependent; negative regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; angiogenesis; heart looping
Research Articles on HAND2
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Product Notes
The Rat HAND2 hand2 (Catalog #AAA9322027) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322027 ELISA Kit recognizes Rat HAND2. It is sometimes possible for the material contained within the vial of "heart and neural crest derivatives expressed 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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