Human heart and neural crest derivatives expressed 1 ELISA Kit | HAND1 elisa kit
Human Heart- and neural crest derivatives-expressed protein 1, HAND1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]
Uniprot Description
HAND1: Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box).
Protein type: DNA-binding; Nucleolus; Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 5q33
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: identical protein binding; protein binding; enzyme binding; protein homodimerization activity; protein heterodimerization activity; transcription coactivator activity; bHLH transcription factor binding; transcription factor binding; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; blastocyst development; mesoderm formation; negative regulation of transcription factor activity; heart development; ventricular cardiac muscle morphogenesis; embryonic heart tube development; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; heart looping; negative regulation of transcription, DNA-dependent; odontogenesis of dentine-containing teeth; trophectodermal cell differentiation
Research Articles on HAND1
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Product Notes
The Human HAND1 hand1 (Catalog #AAA9328169) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328169 ELISA Kit recognizes Human HAND1. It is sometimes possible for the material contained within the vial of "heart and neural crest derivatives expressed 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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