Hamster Solute Carrier Family 22 Member 1 (SLC22A1) ELISA Kit | SLC22A1 elisa kit
Hamster Solute Carrier Family 22 Member 1 (SLC22A1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
polyspecific transporter involved in exporting ATP-dependent multidrug proteins through the basolateral membrane of renal proximal tubules [RGD, Feb 2006]
Uniprot Description
SLC22A1: Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter
Cellular Component: basolateral plasma membrane; integral to plasma membrane
Molecular Function: acetylcholine transmembrane transporter activity; dopamine transmembrane transporter activity; identical protein binding; monoamine transmembrane transporter activity; norepinephrine transmembrane transporter activity; organic cation transmembrane transporter activity; protein homodimerization activity; quaternary ammonium group transmembrane transporter activity; secondary active organic cation transmembrane transporter activity
Biological Process: cation transport; dopamine transport; epinephrine transport; establishment and/or maintenance of transmembrane electrochemical gradient; monoamine transport; multidrug transport; neurotransmitter transport; norepinephrine transport; organic cation transport; protein homooligomerization; quaternary ammonium group transport
Research Articles on SLC22A1
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Product Notes
The Hamster SLC22A1 slc22a1 (Catalog #AAA9345469) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9345469 ELISA Kit recognizes Hamster SLC22A1. It is sometimes possible for the material contained within the vial of "Solute Carrier Family 22 Member 1 (SLC22A1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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