Guinea Pig Metabotropic glutamate receptor 6 (GRM6) ELISA Kit | GRM6 elisa kit
Guinea pig Metabotropic glutamate receptor 6 (GRM6) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
has adenylate cyclase inhibiting metabotropic glutamate receptor activity; may play a role in synaptic transmission between photoreceptor cells and ON-bipolar cells in the retina [RGD, Feb 2006]
Uniprot Description
mGluR6: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B). This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background. Belongs to the G-protein coupled receptor 3 family.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 3
Cellular Component: Golgi membrane; presynaptic membrane; endoplasmic reticulum membrane; integral to plasma membrane; dendrite; integral to membrane
Molecular Function: adenylate cyclase inhibiting metabotropic glutamate receptor activity; group III metabotropic glutamate receptor activity; protein homodimerization activity; glutamate receptor activity
Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; retina development in camera-type eye; sensory perception of light stimulus; metabotropic glutamate receptor signaling pathway; detection of light stimulus involved in visual perception; locomotory behavior; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; signal transduction
Research Articles on GRM6
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Product Notes
The Guinea Pig GRM6 grm6 (Catalog #AAA7204990) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7204990 ELISA Kit recognizes Guinea Pig GRM6. It is sometimes possible for the material contained within the vial of "Metabotropic glutamate receptor 6 (GRM6), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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