Guinea Pig E3 ubiquitin-protein ligase TRAF7 ELISA Kit | TRAF7 elisa kit
Guinea pig E3 ubiquitin-protein ligase TRAF7 (TRAF7) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
Uniprot Description
TRAF7: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Belongs to the WD repeat TRAF7 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase; Ligase
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytoplasmic membrane-bound vesicle; cytosol; intracellular membrane-bound organelle; nucleus; perinuclear region of cytoplasm; plasma membrane; ubiquitin ligase complex
Molecular Function: ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: activation of MAPKKK activity; apoptosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of MAPKKK cascade; positive regulation of protein sumoylation; protein ubiquitination; regulation of protein localization; transcription, DNA-dependent
