Guinea Pig Dihydrofolate reductase (DHFR) ELISA Kit | DHFR elisa kit
Guinea pig Dihydrofolate reductase (DHFR) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
DHFR: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1. Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD). DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms. Belongs to the dihydrofolate reductase family.
Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.3; Oxidoreductase
Molecular Function: mRNA binding; dihydrofolic acid binding; RNA binding; dihydrofolate reductase activity; oxidoreductase activity; drug binding; NADP binding
Biological Process: tetrahydrofolate metabolic process; tetrahydrofolate biosynthetic process; nucleotide biosynthetic process; dihydrofolate metabolic process; one-carbon compound metabolic process; response to methotrexate; glycine biosynthetic process
Research Articles on DHFR
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Product Notes
The Guinea Pig DHFR dhfr (Catalog #AAA7237908) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7237908 ELISA Kit recognizes Guinea Pig DHFR. It is sometimes possible for the material contained within the vial of "Dihydrofolate reductase (DHFR), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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