Guinea Pig Cytoskeleton-associated protein 5 (CKAP5) ELISA Kit | CKAP5 elisa kit
Guinea pig Cytoskeleton-associated protein 5 (CKAP5) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Uniprot Description
CKAP5: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. Belongs to the TOG/XMAP215 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: microtubule cytoskeleton; spindle pole; centrosome; protein complex; membrane; cytosol; gamma-tubulin complex
Molecular Function: protein binding
Biological Process: mitosis; centrosome organization and biogenesis; cell division; organelle organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; spindle organization and biogenesis; RNA transport; establishment and/or maintenance of microtubule cytoskeleton polarity
Research Articles on CKAP5
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Product Notes
The Guinea Pig CKAP5 ckap5 (Catalog #AAA7230463) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7230463 ELISA Kit recognizes Guinea Pig CKAP5. It is sometimes possible for the material contained within the vial of "Cytoskeleton-associated protein 5 (CKAP5), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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