Guinea Pig Centromere protein N (CENPN) ELISA Kit | CENPN elisa kit
Guinea pig Centromere protein N (CENPN) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Description
CENPN: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 16q23.2
Cellular Component: nucleoplasm; cytosol; nucleus
Biological Process: mitosis; nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle; chromosome segregation
Research Articles on CENPN
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Product Notes
The Guinea Pig CENPN cenpn (Catalog #AAA7232950) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7232950 ELISA Kit recognizes Guinea Pig CENPN. It is sometimes possible for the material contained within the vial of "Centromere protein N (CENPN), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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