Mouse Gasdermin D ELISA Kit | GSDMD elisa kit

Mouse Gasdermin D ELISA Kit

Cat. Num. AAA7256080

• Gene Names: GSDMD; DF5L; DFNA5L; FKSG10; GSDMDC1
• Reactivity: Mouse
• Synonyms: Gasdermin D; Mouse Gasdermin D ELISA Kit; GSDMD elisa kit

• Reactivity: Mouse
• Sequence Length: 484

• Reproducibility: Intra-Assay: CV<10%; Inter-Assay: CV<15%
• Reactivity Note: No significant cross-reactivity or interference between this antigen and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection, therefore, cross reaction may still exist in some cases.
• Preparation and Storage: Store at 2-8 degree C.; The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.

Related Product Information for GSDMD elisa kit

This ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of the targets.

NCBI and Uniprot Product Information

• NCBI GI #: 261878494
• NCBI GeneID: 79792
• NCBI Accession #: NP_001159709.1
• NCBI GenBank Nucleotide #: NM_001166237.1
• UniProt Accession #: P57764; Q96Q98; A8K702; D3DWJ9
• Molecular Weight: 52,801 Da
• NCBI Official Full Name: gasdermin-D
• NCBI Official Synonym Full Names: gasdermin D
• NCBI Official Symbol: GSDMD
• NCBI Official Synonym Symbols: DF5L; DFNA5L; FKSG10; GSDMDC1
• NCBI Protein Information: gasdermin-D
• UniProt Protein Name: Gasdermin-D
• Protein Family: Gasdermin
• UniProt Gene Name: GSDMD
• UniProt Synonym Gene Names: DFNA5L; GSDMDC1; GSDMD-NT; GSDMD-CT

NCBI Description

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Uniprot Description

Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators (PubMed:26375003, PubMed:26375259, PubMed:27418190). After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to phosphatidic acid and phosphatidylserine (PubMed:27281216). Homooligomerizes within the membrane and forms pores of 10 - 15 nanometers (nm) of inner diameter, possibly allowing the release of mature IL1B and triggering pyroptosis (PubMed:27418190, PubMed:27281216). Exhibits bactericidal activity. Gasdermin-D, N-terminal released from pyroptotic cells into the extracellular milieu rapidly binds to and kills both Gram-negative and Gram-positive bacteria, without harming neighboring mammalian cells, as it does not disrupt the plasma membrane from the outside due to lipid-binding specificity (PubMed:27281216). Under cell culture conditions, also active against intracellular bacteria, such as Listeria monocytogenes (). Strongly binds to bacterial and mitochondrial lipids, including cardiolipin. Does not bind to unphosphorylated phosphatidylinositol, phosphatidylethanolamine nor phosphatidylcholine (PubMed:27281216).