Human Alanine aminotransferase 2 ELISA Kit | GPT2 elisa kit
Human Alanine aminotransferase 2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Description
GPT2: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.2; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: 16q11.2
Cellular Component: mitochondrial matrix
Molecular Function: alanine transaminase activity
Biological Process: 2-oxoglutarate metabolic process; amino acid biosynthetic process; L-alanine metabolic process
Disease: Mental Retardation, Autosomal Recessive 49
Research Articles on GPT2
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Product Notes
The Human GPT2 gpt2 (Catalog #AAA9425432) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9425432 ELISA Kit recognizes Human GPT2. It is sometimes possible for the material contained within the vial of "Alanine aminotransferase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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