Glycerol-3-Phosphate Dehydrogenase 2 Recombinant Protein | GPD2 recombinant protein
Recombinant Human Glycerol-3-Phosphate Dehydrogenase 2
Introduction: GPD2 (Mitochondrial glycerol-3-phosphate dehydrogenase) is a Ca2+-sensitive, FAD-binding protein, which is located on the outer surface of the inner mitochondrial membrane. Two isoforms have been identified for mGPD: Isoform 1 is comprised of 727 a.a. residues, while isoform 2 lacks 126 a.a. residues of the N-terminus. GPD2 catalyses the oxidation of glycerol-3-phosphate to DHAP (dihydroxyacetone phosphate) with associated reduction of the enzyme-bound FAD. GPD2 is a testis-specific promoter of mitochondrial GPDH. GPD2 along with a cytosolic NAD-linked GPD forms the glycerol phosphate shuttle that uses the interconversion of G-3-P and DHAP to transfer reducing equivalents into mitochondria, which results in the reoxidation of NADH produced during glycolysis.GPD2 deficiency contributes to the impairment of glucose-stimulated insulin discharge in a number of animal models of non-insulin dependent diabetes mellitus. GPD2 up-regulation as a result of a highly glycolytic environment contributes to the general increase in ROS generation and may lead to the progression of prostate cancer.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Description
GPD2: localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Protein type: EC 1.1.5.3; Oxidoreductase; Lipid Metabolism - glycerophospholipid; Mitochondrial; Calcium-binding
Chromosomal Location of Human Ortholog: 2q24.1
Cellular Component: glycerol-3-phosphate dehydrogenase complex; mitochondrial inner membrane
Molecular Function: glycerol-3-phosphate dehydrogenase activity; calcium ion binding
Biological Process: glycerol-3-phosphate metabolic process; camera-type eye development; multicellular organism growth; cellular lipid metabolic process; gluconeogenesis; glycerol catabolic process
Disease: Diabetes Mellitus, Noninsulin-dependent
Research Articles on GPD2
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Product Notes
The GPD2 gpd2 (Catalog #AAA143667) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Glycerol-3-Phosphate Dehydrogenase 2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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