Pre-glycoprotein polyprotein GP complex (GPC) Recombinant Protein | PICV_gp1 recombinant protein
Recombinant Pichinde arenavirus Pre-glycoprotein polyprotein GP complex (GPC)
NCBI and Uniprot Product Information
Uniprot Description
Function: The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion
By similarity.Glycoprotein G1 binds to the host receptor
Potential.Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome
Potential.
Subunit structure: Glycoprotein G1 is a homotetramer; disulfide-linked
Potential. Glycoprotein G2 is a homotetramer
Potential. GP2 homotetramers bind through ionic interactions with GP1 homotetramers to form, with the stable signal peptide, the GP complex. The GP-C polyprotein interacts with host protease MBTPS1/SKI-1; this results in polyprotein processing
By similarity.
Subcellular location: Stable signal peptide: Virion membrane; Multi-pass membrane protein
Potential. Host endoplasmic reticulum membrane; Multi-pass membrane protein
Potential. Host Golgi apparatus membrane; Multi-pass membrane protein
Potential. Host cell membrane; Multi-pass membrane protein
Potential. Glycoprotein G1: Virion membrane; Peripheral membrane protein
Potential. Host endoplasmic reticulum membrane; Peripheral membrane protein
Potential. Host Golgi apparatus membrane; Peripheral membrane protein
Potential. Host cell membrane; Peripheral membrane protein
Potential. Glycoprotein G2: Virion membrane; Single-pass membrane protein
Potential. Host endoplasmic reticulum membrane; Single-pass membrane protein
Potential. Host Golgi apparatus membrane; Single-pass membrane protein
Potential. Host cell membrane; Single-pass membrane protein
Potential. Note: Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly
By similarity.
Domain: The cytoplasmic domain of GP2 plays a role in ER location and binds to the SSP.
Post-translational modification: The SSP remains stably associated with the GP complex following cleavage by signal peptidase and plays crucial roles in the trafficking of GP through the secretory pathway
By similarity.Specific enzymatic cleavages in vivo yield mature proteins. GP-C polyprotein is cleaved in the endoplasmic reticulum by the host protease MBTPS1. Only cleaved glycoprotein is incorporated into virions.
Sequence similarities: Belongs to the arenaviridae GPC protein family.
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Product Notes
The PICV_gp1 gpc (Catalog #AAA1244074) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 274-503. The amino acid sequence is listed below: GFFTWDLSDS SGQHVPGGYC LEQWAIIWAG IKCFDNTVMA KCNKDHNEEF CDTMRLFDFN QNAIKTLQLN VENSLNLFKK TINGLISDSL VIRNSLKQLA KIPYCNYTKF WYINDTITGR HSLPQCWLVH NGSYLNETHF KNDWLWESQN LYNEMLMKEY EERQGKTPLA LTDICFWSLV FYTITVFLHI VGIPTHRHII GDGCPKPHRI TRNSLCSCGY YKYQRNLTNG. It is sometimes possible for the material contained within the vial of "Pre-glycoprotein polyprotein GP complex (GPC), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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