Mouse Platelet glycoprotein Ib alpha chain ELISA Kit | Gp1ba elisa kit

Mouse Platelet glycoprotein Ib alpha chain ELISA Kit

Cat. Num. AAA2881150

• Gene Names: Gp1ba; GPIba; GPIbalpha
• Reactivity: Mouse
• Synonyms: Platelet glycoprotein Ib alpha chain; Mouse Platelet glycoprotein Ib alpha chain ELISA Kit; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Gp1ba; CD42b; Gp1ba elisa kit

• Reactivity: Mouse
• Sequence Length: 734

• Assay Type: Sandwich
• Detection Range: 31.2-2000 pg/mL
• Sensitivity: 15.82 pg/mL
• Intra-Assay CV: <=5.7%
• Inter-Assay CV: <=8.1%
• Recovery: 108%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 158635962
• NCBI GeneID: 14723
• NCBI Accession #: NP_034456.2
• NCBI GenBank Nucleotide #: NM_010326.2
• UniProt Accession #: O35930; Q5SX47
• Molecular Weight: 80,055 Da
• NCBI Official Full Name: platelet glycoprotein Ib alpha chain
• NCBI Official Synonym Full Names: glycoprotein 1b, alpha polypeptide
• NCBI Official Symbol: Gp1ba
• NCBI Official Synonym Symbols: GPIba; GPIbalpha
• NCBI Protein Information: platelet glycoprotein Ib alpha chain
• UniProt Protein Name: Platelet glycoprotein Ib alpha chain
• Protein Family: Platelet glycoprotein
• UniProt Gene Name: Gp1ba
• UniProt Synonym Gene Names: GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha
• UniProt Entry Name: GP1BA_MOUSE

Uniprot Description

GPIbA: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. Genetic variations in GP1BA may be a cause of susceptibility to non-arteritic anterior ischemic optic neuropathy (NAION). NAION is an ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage. Defects in GP1BA are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. Defects in GP1BA are the cause of benign mediterranean macrothrombocytopenia (BMM); also known as autosomal dominant benign Bernard-Soulier syndrome. BMM is characterized by mild or no clinical symptoms, normal platelet function, and normal megakaryocyte count. Defects in GP1BA are the cause of pseudo-von Willebrand disease (VWDP). A bleeding disorder is caused by an increased affinity of GP-Ib for soluble vWF resulting in impaired hemostatic function due to the removal of vWF from the circulation.

Protein type: Cell adhesion; Cell surface; Membrane protein, integral

Cellular Component: anchored to external side of plasma membrane; cell surface; cytoplasm; integral to membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: protein kinase inhibitor activity

Biological Process: blood coagulation; cell adhesion; cell morphogenesis; cytokine and chemokine mediated signaling pathway; fibrinolysis; hemostasis; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity