SDS-PAGE
Pre-small/secreted glycoprotein Recombinant Protein | GP recombinant protein
Recombinant Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus) Pre-small/secreted glycoprotein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Pre-small/secreted glycoprotein; Recombinant Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus) Pre-small/secreted glycoprotein; Cleaved into the following 2 chains: 1. Small/secreted glycoprotein; 2. sGP; 3. Delta-peptide; GP recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
33-364. Full length of the mature protein.
Sequence
IPLGVIHNSTLQVNDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKTSLEKFAVKSCLSQLYQTEPKTSVVRVRRELLPTQGPTQQLKTTKSWLQKIPLQWFKCTVKEGKLQCRI
Sequence Length
364
Species
Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
SDS-PAGE
SDS-PAGE
Related Product Information for GP recombinant protein
sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. Does not seem to be involved in activation of primary macrophages. Does not seem to interact specifically with neutrophils
Delta-peptide does not seem to be involved in activation of primary macrophages.
References
"Emergence of subtype Zaire Ebola virus in Gabon."
Volchkov V., Volchkova V., Eckel C., Klenk H.-D., Bouloy M., Leguenno B., Feldmann H.
Virology 232:139-144(1997)
NCBI and Uniprot Product Information
NCBI GI #
UniProt Accession #
Molecular Weight
39.3 kDa
NCBI Official Full Name
Pre-small/secreted glycoprotein
UniProt Protein Name
Pre-small/secreted glycoprotein
Protein Family
UniProt Gene Name
GP
UniProt Synonym Gene Names
pre-sGP; sGP
UniProt Entry Name
VSGP_EBOEC
Uniprot Description
sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. Does not seem to be involved in activation of primary macrophages. Does not seem to interact specifically with neutrophils ().
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Product Notes
The GP gp (Catalog #AAA1245951) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 33-364. Full length of the mature protein. The amino acid sequence is listed below: IPLGVIHNST LQVNDVDKLV CRDKLSSTNQ LRSVGLNLEG NGVATDVPSA TKRWGFRSGV PPKVVNYEAG EWAENCYNLE IKKPDGSECL PAAPDGIRGF PRCRYVHKVS GTGPCAGDFA FHKEGAFFLY DRLASTVIYR GTTFAEGVVA FLILPQAKKD FFSSHPLREP VNATEDPSSG YYSTTIRYQA TGFGTNETEY LFEVDNLTYV QLESRFTPQF LLQLNETIYT SGKRSNTTGK LIWKVNPEID TTIGEWAFWE TKKTSLEKFA VKSCLSQLYQ TEPKTSVVRV RRELLPTQGP TQQLKTTKSW LQKIPLQWFK CTVKEGKLQC RI . It is sometimes possible for the material contained within the vial of "Pre-small/secreted glycoprotein, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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