SDS-PAGE
Aspartate aminotransferase, mitochondrial Recombinant Protein | GOT2 recombinant protein
Recombinant human Aspartate aminotransferase, mitochondrial
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
NCBI Description
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Ref.6
Catalytic activity: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor: Pyridoxal phosphate.
Subunit structure: Homodimer.
Subcellular location: Mitochondrion matrix. Cell membrane. Note: Exposure to alcohol promotes translocation to the cell membrane. Ref.6
Induction: Up-regulated by long-time exposure to alcohol. Ref.6
Miscellaneous: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Sequence similarities: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Research Articles on GOT2
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Product Notes
The GOT2 got2 (Catalog #AAA717285) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: WTHVEMGPPD PILGVTEAFK RDTNSKKMNL GVGAYRDDNG KPYVLPSVRK AEAQIAAKNL DKEYLPIGGL AEFCKASAEL ALGENSEVLK SGRFVTVQTI SGTGALRIGA SFLQRFFKFS RDVFLPKPTW GNHTPIFRDA GMQLQGYRYY DPKTCGFDFT GAVEDISKIP EQSVLLLHAC AHNPTGVDPR PEQWKEIATV VKKRNLFAFF DMAYQGFASG DGDKDAWAVR HFIEQGINVC LCQSYAK. It is sometimes possible for the material contained within the vial of "Aspartate aminotransferase, mitochondrial, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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