Goat Proteasome Activator Complex Subunit 3 (PSME3) ELISA Kit | PSME3 elisa kit

Goat Proteasome Activator Complex Subunit 3 (PSME3) ELISA Kit

Cat. Num. AAA7259754

• Gene Names: PSME3; Ki; PA28G; HEL-S-283; PA28gamma; REG-GAMMA; PA28-gamma
• Reactivity: Goat
• Synonyms: Proteasome Activator Complex Subunit 3 (PSME3); Goat Proteasome Activator Complex Subunit 3 (PSME3) ELISA Kit; PSME3 elisa kit

• Reactivity: Goat
• Sequence Length: 265

• Reproducibility: Intra-Assay: CV<10%; Inter-Assay: CV<15%
• Reactivity Note: No significant cross-reactivity or interference between this antigen and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection, therefore, cross reaction may still exist in some cases.
• Preparation and Storage: Store at 2-8 degree C.; The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.

Related Product Information for PSME3 elisa kit

This ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of the targets.

Product Categories/Family for PSME3 elisa kit

Cell Biology; Immunology; Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 388556516
• NCBI GeneID: 10197
• NCBI Accession #: NP_001253974.1
• NCBI GenBank Nucleotide #: NM_001267045.1
• Molecular Weight: 30,887 Da
• NCBI Official Full Name: proteasome activator complex subunit 3 isoform 3
• NCBI Official Synonym Full Names: proteasome activator subunit 3
• NCBI Official Symbol: PSME3
• NCBI Official Synonym Symbols: Ki; PA28G; HEL-S-283; PA28gamma; REG-GAMMA; PA28-gamma
• NCBI Protein Information: proteasome activator complex subunit 3
• UniProt Protein Name: Proteasome activator complex subunit 3
• Protein Family: Proteasome activator
• UniProt Gene Name: PSME3
• UniProt Synonym Gene Names: REG-gamma; PA28g; PA28gamma

NCBI Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Uniprot Description

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).