Goat Anti-Complement 1q Antibody Anti-Complement 1q Antibody (Anti-C1q) ELISA Kit | C1q elisa kit

Goat Anti-Complement 1q Antibody Anti-Complement 1q Antibody (Anti-C1q) ELISA Kit

Cat. Num. AAA264459

• Gene Names: C1QC; C1QG; C1Q-C
• Reactivity: Goat
• Synonyms: Anti-Complement 1q Antibody Anti-Complement 1q Antibody (Anti-C1q); Goat Anti-Complement 1q Antibody Anti-Complement 1q Antibody (Anti-C1q) ELISA Kit; C1q elisa kit

• Reactivity: Goat
• Sequence Length: 245

• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 56786155
• NCBI GeneID: 714
• NCBI Accession #: NP_758957.2
• NCBI GenBank Nucleotide #: NM_172369.3
• Molecular Weight: 25,774 Da
• NCBI Official Full Name: complement C1q subcomponent subunit C
• NCBI Official Synonym Full Names: complement component 1, q subcomponent, C chain
• NCBI Official Symbol: C1QC
• NCBI Official Synonym Symbols: C1QG; C1Q-C
• NCBI Protein Information: complement C1q subcomponent subunit C; complement component 1, q subcomponent, gamma polypeptide
• UniProt Protein Name: Complement C1q subcomponent subunit C
• UniProt Gene Name: C1QC
• UniProt Synonym Gene Names: C1QG
• UniProt Entry Name: C1QC_HUMAN

NCBI Description

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: extracellular space; collagen; extracellular region

Biological Process: negative regulation of macrophage differentiation; innate immune response; immune response; complement activation, classical pathway; complement activation; negative regulation of granulocyte differentiation

Disease: C1q Deficiency