Western Blot (WB)
(MBS420877 (1ug/ml) staining of Human Amylgada (A) and Rat (B) Brain lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.)
Goat NMDA receptor 1/GRIN1 Antibody | anti-GRIN1 antibody
Goat anti-NMDA receptor 1/GRIN1 Antibody
Western Blot: Approx 100kDa band observed in Human Brain (Amylgada) and Rat Brain lysates (calulated MW of 101kDa according to Human NP_067544.1 and Rat NP_001257534.1. Recommended concentration: 1-3ug/ml. Primary incubation was 1 hour. Preliminary testing was unsuccessful on Mouse for this particular batch.
Western Blot (WB)
(MBS420877 (1ug/ml) staining of Human Amylgada (A) and Rat (B) Brain lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.)
Western Blot (WB)
(MBS420877 (1ug/ml) staining of Human Amylgada (A) and Rat (B) Brain lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described.
Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, calcium
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: cell junction; cell soma; cell surface; dendrite; dendritic spine; endoplasmic reticulum; excitatory synapse; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; synaptic vesicle; terminal button
Molecular Function: calcium channel activity; calcium ion binding; calmodulin binding; enzyme binding; extracellular-glutamate-gated ion channel activity; glutamate binding; glutamate receptor binding; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; neurotransmitter binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; voltage-gated cation channel activity
Biological Process: adult locomotory behavior; calcium ion homeostasis; cation transport; cellular calcium ion homeostasis; cerebral cortex development; conditioned taste aversion; ephrin receptor signaling pathway; ionotropic glutamate receptor signaling pathway; long-term memory; male mating behavior; MAPKKK cascade; negative regulation of neuron apoptosis; olfactory learning; pons maturation; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of transcription from RNA polymerase II promoter; prepulse inhibition; propylene metabolic process; protein tetramerization; regulation of axonogenesis; regulation of dendrite morphogenesis; regulation of excitatory postsynaptic membrane potential; regulation of long-term neuronal synaptic plasticity; regulation of membrane potential; regulation of respiratory gaseous exchange; regulation of synaptogenesis; respiratory gaseous exchange; response to amphetamine; response to calcium ion; response to ethanol; response to morphine; rhythmic process; sensory perception of pain; social behavior; suckling behavior; synaptic transmission; synaptic transmission, glutamatergic; visual learning
Disease: Mental Retardation, Autosomal Dominant 8
Research Articles on GRIN1
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Product Notes
The GRIN1 grin1 (Catalog #AAA420877) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-NMDA receptor 1/GRIN1 Antibody reacts with Tested: Human, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's NMDA receptor 1/GRIN1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 1000. Western Blot: Approx 100kDa band observed in Human Brain (Amylgada) and Rat Brain lysates (calulated MW of 101kDa according to Human NP_067544.1 and Rat NP_001257534.1. Recommended concentration: 1-3ug/ml. Primary incubation was 1 hour. Preliminary testing was unsuccessful on Mouse for this particular batch. Researchers should empirically determine the suitability of the GRIN1 grin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NMDA receptor 1/GRIN1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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