Western Blot (WB)
(MBS421389 (1ug/ml) staining of Human Breast (A) and Breast cancer (B) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat RARA Antibody | anti-RARA antibody
Goat anti-RARA Antibody
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Western Blot: Approx 55kDa band observed in Human Breast and Breast cancer lysates (calculated MW of 50.8kDa according to NP_000955.1; NP_001019980.1). Recommended concentration: 0.5-2ug/ml.
Western Blot (WB)
(MBS421389 (1ug/ml) staining of Human Breast (A) and Breast cancer (B) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
(MBS421389 (1ug/ml) staining of Human Breast (A) and Breast cancer (B) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Uniprot Description
RARA: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARA is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Its phosphorylation is crucial for transcriptional activity. Aberrations involving RARA may be a cause of acute promyelocytic leukemia. Two splice-variant isoforms have been described.
Protein type: DNA-binding; Nuclear receptor; Transcription factor; Oncoprotein
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: actin cytoskeleton; cell soma; cell surface; cytoplasm; dendrite; nuclear chromatin; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: alpha-actinin binding; chromatin DNA binding; drug binding; enzyme binding; histone deacetylase binding; mRNA 5'-UTR binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase A binding; protein kinase B binding; receptor binding; retinoic acid binding; retinoic acid receptor activity; steroid hormone receptor activity; transcription coactivator activity; transcription corepressor activity; transcription factor activity; transcription factor binding; translation repressor activity, nucleic acid binding; zinc ion binding
Biological Process: apoptotic cell clearance; embryonic camera-type eye development; female pregnancy; germ cell development; glandular epithelial cell development; hippocampus development; limb development; liver development; multicellular organism growth; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of granulocyte differentiation; negative regulation of interferon-gamma production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of translational initiation; negative regulation of tumor necrosis factor production; neural tube closure; positive regulation of binding; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-5 production; positive regulation of neuron differentiation; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; prostate gland development; protein amino acid phosphorylation; regulation of myelination; regulation of synaptic plasticity; response to cytokine stimulus; response to estradiol stimulus; response to ethanol; response to retinoic acid; response to vitamin A; retinoic acid receptor signaling pathway; Sertoli cell fate commitment; signal transduction; spermatogenesis; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter; ureteric bud development; ventricular cardiac muscle cell differentiation
Disease: Acute Promyelocytic Leukemia
Research Articles on RARA
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Product Notes
The RARA rara (Catalog #AAA421389) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-RARA Antibody reacts with Tested: Human Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's RARA can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 55kDa band observed in Human Breast and Breast cancer lysates (calculated MW of 50.8kDa according to NP_000955.1; NP_001019980.1). Recommended concentration: 0.5-2ug/ml. Researchers should empirically determine the suitability of the RARA rara for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: SPSLSPSSHR SSPATQSP. It is sometimes possible for the material contained within the vial of "RARA, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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