Goat Apolipoprotein CIII Antibody | anti-Apo CIII antibody

Goat Anti-Human Apolipoprotein CIII Affinity Pure

Cat. Num. AAA390097

• Gene Names: APOC3; HALP2; APOCIII
• Applications: ELISA, Immunoblot, Western Blot
• Synonyms: Apolipoprotein CIII; Goat Anti-Human Apolipoprotein CIII Affinity Pure; Goat Anti-Human Apolipoprotein CIII (Apo CIII); Polyclonal Antibody; Affinity Purified; anti-Apo CIII antibody

• Host: Goat
• Specificity: Specifically binds to human apo CIII. Dilution for Immunoblot & ELISA range: 200 to 40,000. Centrifuge before use.
• Concentration: 1 mg / ml (OD. 1.35 / 280 nm). (varies by lot)
• Sequence Length: 99

• Applicable Applications for anti-Apo CIII antibody: ELISA (EIA), Immunoblot (IB)
• Application Notes: Dilution for Immunoblot & ELISA range: 1,000 to 40,000.; Use: The antibody can be used for detection of apo CIII in human plasma and lipoproteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation.
• Source Note: Polyclonal antibody purified by human apo CIII-Sepharose
• Preservative: In 75 mM Sodium Phosphate, 75 mM NaCl, O.5 mM EDTA, 0.02% NaN3, pH 7.2.
• Preparation and Storage: -20o C for long-term storage, 4o C for short-term storage. Aliquot to avoid repeated thaw and freeze.

Testing Data)

Product Categories/Family for anti-Apo CIII antibody

Aff. Pure AB

NCBI and Uniprot Product Information

• NCBI GI #: 4557323
• NCBI GeneID: 345
• NCBI Accession #: NP_000031.1
• NCBI GenBank Nucleotide #: NM_000040.1
• UniProt Accession #: P02656; Q08E83; Q6Q786
• Molecular Weight: 10,852 Da
• NCBI Official Full Name: apolipoprotein C-III
• NCBI Official Synonym Full Names: apolipoprotein C-III
• NCBI Official Symbol: APOC3
• NCBI Official Synonym Symbols: HALP2; APOCIII
• NCBI Protein Information: apolipoprotein C-III; apo-CIII; apoC-III; apolipoprotein C3
• UniProt Protein Name: Apolipoprotein C-III
• UniProt Gene Name: APOC3
• UniProt Synonym Gene Names: Apo-CIII; ApoC-III
• UniProt Entry Name: APOC3_HUMAN

NCBI Description

Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.

Subcellular location: Secreted.

Tissue specificity: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.

Post-translational modification: The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. Ref.11 Ref.12

Involvement in disease: Hyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13

Sequence similarities: Belongs to the apolipoprotein C3 family.