Rat guanine nucleotide binding protein, alpha transducing 3 ELISA Kit | GNAT3 elisa kit
Rat Guanine nucleotide-binding protein G, GNAT3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
G protein alpha-subunit of taste tissue [RGD, Feb 2006]
Uniprot Description
G-alpha t3: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide- 1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Protein type: G protein, heterotrimeric alpha G((i/o/t/z)); G protein; G protein, heterotrimeric
Cellular Component: protein complex; photoreceptor outer segment; photoreceptor inner segment; cytoplasm; apical plasma membrane; acrosome; heterotrimeric G-protein complex; axoneme
Molecular Function: GTPase activity; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; G-protein coupled photoreceptor activity
Biological Process: response to nicotine; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; sensory perception of umami taste; sensory perception of sweet taste; sensory perception of taste; visual perception; metabolic process; sensory perception of bitter taste; detection of chemical stimulus involved in sensory perception of bitter taste; detection of visible light
Research Articles on GNAT3
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Product Notes
The Rat GNAT3 gnat3 (Catalog #AAA9333421) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333421 ELISA Kit recognizes Rat GNAT3. It is sometimes possible for the material contained within the vial of "guanine nucleotide binding protein, alpha transducing 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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