Rat guanine nucleotide binding protein (G protein) , alpha inhibiting activity polypeptide 3 ELISA Kit | GNAI3 elisa kit

Rat Guanine nucleotide-binding protein G, GNAI3 ELISA Kit

Cat. Num. AAA9331856

• Gene Names: Gnai3; GIP3A
• Reactivity: Rat
• Synonyms: guanine nucleotide binding protein (G protein); alpha inhibiting activity polypeptide 3; Rat Guanine nucleotide-binding protein G; GNAI3 ELISA Kit; Rat Guanine nucleotide-binding protein G (GNAI3) ELISA kit; 87U6; FLJ26559; ; GNAI3 elisa kit

• Reactivity: Rat

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 6980964
• NCBI GeneID: 25643
• NCBI Accession #: NP_037238.1
• NCBI GenBank Nucleotide #: NM_013106.1
• UniProt Accession #: P08753
• Molecular Weight: 40,522 Da
• NCBI Official Full Name: guanine nucleotide-binding protein G(k) subunit alpha
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
• NCBI Official Symbol: Gnai3
• NCBI Official Synonym Symbols: GIP3A
• NCBI Protein Information: guanine nucleotide-binding protein G(k) subunit alpha; guanine nucleotide-binding protein G(k) subunit alpha; g(i) alpha-3; guanine nucleotide binding protein, alpha inhibiting 3; guanine nucleotide binding protein (G protein), alpha inhibiting 3; Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3
• UniProt Protein Name: Guanine nucleotide-binding protein G(k) subunit alpha
• UniProt Gene Name: Gnai3
• UniProt Synonym Gene Names: Gnai-3
• UniProt Entry Name: GNAI3_RAT

NCBI Description

has GTPase activity; involved in zymogen granule-plasma membrane fusion in pancreatic cells [RGD, Feb 2006]

Uniprot Description

G-alpha i3: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1). ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Protein type: G protein, heterotrimeric alpha G((i/o/t/z)); G protein, heterotrimeric; G protein

Cellular Component: Golgi membrane; Golgi apparatus; centrosome; membrane; lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; midbody; lipid raft

Molecular Function: GTPase activity; protein domain specific binding; protein binding; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding

Biological Process: vesicle fusion; G-protein signaling, coupled to cAMP nucleotide second messenger; cell division; metabolic process; negative regulation of secretion; regulation of heart contraction