Mouse Glomulin ELISA Kit | GLMN elisa kit

Mouse Glomulin (GLMN) ELISA Kit

Cat. Num. AAA284034

• Gene Names: Glmn; Fap48; Fap68; AW227515; 9330160J16Rik
• Reactivity: Mouse
• Synonyms: Glomulin; Mouse Glomulin (GLMN) ELISA Kit; FAP; FAP48; FAP68; FKBPAP; GLML; GVM; VMGLOM; FK506-binding protein-associated protein|glomulin; GLMN elisa kit

• Reactivity: Mouse
• Specificity: This assay has high sensitivity and excellent specificity for detection of Mouse GLMN. No significant cross-reactivity or interference between Mouse GLMN and analogues was observed.
• Sequence Length: 594

• Samples: Serum, Plasma, Other biological fluids
• Assay Type: Sandwich
• Sample Volume: 1-200 uL
• Precision: Intra-assay Precision (Precision within an assay); Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.; Inter-assay Precision (Precision between assays); Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.; CV (%) = SD/meanX100; Intra-Assay: CV; Inter-Assay: CV
• Detection Wavelength: 450 nm
• Preparation and Storage: Store at 2-8 degree C.

Related Product Information for GLMN elisa kit

Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate GLMN in samples. An antibody specific for GLMN has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyGLMN present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for GLMN is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of GLMN bound in the initial step. The color development is stopped and the intensity of the color is measured.

NCBI and Uniprot Product Information

• NCBI GI #: 239985599
• NCBI GeneID: 170823
• NCBI Accession #: NP_001155210.1
• NCBI GenBank Nucleotide #: NM_001161738.1
• UniProt Accession #: Q8BZM1; Q3TFR5; Q99LB8
• Molecular Weight: 67,756 Da
• NCBI Official Full Name: glomulin isoform a
• NCBI Official Synonym Full Names: glomulin, FKBP associated protein
• NCBI Official Symbol: Glmn
• NCBI Official Synonym Symbols: Fap48; Fap68; AW227515; 9330160J16Rik
• NCBI Protein Information: glomulin
• UniProt Protein Name: Glomulin
• Protein Family: Glomulin
• UniProt Gene Name: Glmn
• UniProt Synonym Gene Names: Fap48; FAP

Uniprot Description

GLMN: Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. Defects in GLMN are the cause of glomuvenous malformations (GVMs). GVMs are characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 5|5 E5

Cellular Component: Cul2-RING ubiquitin ligase complex; cullin-RING ubiquitin ligase complex; cytoplasm

Molecular Function: hepatocyte growth factor receptor binding; protein binding; receptor binding; ubiquitin protein ligase binding; ubiquitin-protein transferase inhibitor activity

Biological Process: cell surface receptor signaling pathway; muscle cell differentiation; negative regulation of cell proliferation; negative regulation of T cell proliferation; neural tube closure; positive regulation of cytokine secretion; positive regulation of interleukin-2 biosynthetic process; positive regulation of phosphorylation; regulation of gene expression, epigenetic; regulation of proteasomal ubiquitin-dependent protein catabolic process; vasculogenesis