Female germline-specific tumor suppressor gld-1 (gld-1) Recombinant Protein | gld-1 recombinant protein
Recombinant Caenorhabditis elegans Female germline-specific tumor suppressor gld-1 (gld-1)
NCBI and Uniprot Product Information
Uniprot Description
RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence (PubMed:24838563). Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA (PubMed:11562350). Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA (PubMed:19758560). Binds sequences in the 3'-UTR region of tra-2 mRNA (PubMed:24838563). Germ line-specific tumor suppressor essential for oogenesis (PubMed:7601353). Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline (PubMed:7601353, PubMed:11562350, PubMed:24838563). Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation (PubMed:11562350). By regulating cye-1 expression, prevents entry into mitosis in meiotic germline cells (PubMed:19758560, PubMed:21455289).
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Product Notes
The gld-1 gld-1 (Catalog #AAA1427152) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-463, Full length. The amino acid sequence is listed below: MPSCTTPTYG VSTQLESQSS ESPSRSSVMT PTSLDGDNSP RKRFPIIDNV PADRWPSTRR DGWSSVRAPP PARLTLSTNN RHIMSPISSA YSQTPNSLLS PAMFNPKSRS IFSPTLPATP MSYGKSSMDK SLFSPTATEP IEVEATVEYL ADLVKEKKHL TLFPHMFSNV ERLLDDEIGR VRVALFQTEF PRVELPEPAG DMISITEKIY VPKNEYPDYN FVGRILGPRG MTAKQLEQDT GCKIMVRGKG SMRDKSKESA HRGKANWEHL EDDLHVLVQC EDTENRVHIK LQAALEQVKK LLIPAPEGTD ELKRKQLMEL AIINGTYRPM KSPNPARVMT AVPLLSPTPL RSSGPVLMSP TPGSGLPSTT FGGSILSPTL TASNLLGSNV FDYSLLSPSM FDSFSSLQLA SDLTFPKYPT TTSFVNSFPG LFTSASSFAN QTNTNVSPSG ASPSASSVNN TSF. It is sometimes possible for the material contained within the vial of "Female germline-specific tumor suppressor gld-1 (gld-1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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