Gap junction alpha-5 protein (Gja5) Recombinant Protein | Gja5 recombinant protein
Recombinant Rat Gap junction alpha-5 protein (Gja5)
NCBI and Uniprot Product Information
NCBI Description
forms intercellular connoxin channels in gap junctions; mediates cell-cell communication [RGD, Feb 2006]
Uniprot Description
GJA5: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA5 are a cause of familial atrial standstill (FAS). Atrial standstill is an extremely rare arrhythmia, characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. Defects in GJA5 are the cause of familial atrial fibrillation type 11 (ATFB11). ATFB11 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the connexin family. Alpha-type (group II) subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, misc.; Motility/polarity/chemotaxis
Cellular Component: connexon complex; cell projection; integral to plasma membrane; gap junction
Molecular Function: gap junction hemi-channel activity; gap junction channel activity
Biological Process: blood vessel development; negative regulation of glomerular filtration; gap junction assembly; regulation of vasodilation; heart development; positive regulation of vasodilation; protein oligomerization; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure; artery morphogenesis; regulation of systemic arterial blood pressure by renal system process; embryonic heart tube development; angiogenesis; negative regulation of blood pressure; transmembrane transport; skeletal development; potassium ion transport; embryonic limb morphogenesis
Research Articles on Gja5
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Product Notes
The Gja5 gja5 (Catalog #AAA954842) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-356. The amino acid sequence is listed below: GDWSFLGEFL EEVHKHSTVI GKVWLTVLFI FRMLVLGTAA ESSWGDEQAD FRCDTIQPGC QNVCYDQAFP ISHIRYWVLQ IIFVSTPSLV YMGHAMHTVR MQEKQKLREA EKAKEAGGTG TYEYLAEKAE LSCWKEVNGK IVLQGTLLNT YVCTILIRTA MEVAFMVGQY LLYGIFLDTL HVCRRSPCPH PVNCYVSRPT EKNVFIVFMM AVAGLSLFLS LAELYHLGWK KIRQRLAKSR QGDKHQLLGP STSLVQGLTP PPDFNQCLKN SPDEKFFSDF SNNMGSRKNP DPLATEEVPN QEQIPEEGFI HTQYGQKPEQ PSGASAGHRF PQGYHSDKRR LSKASSKARS DDLSV. It is sometimes possible for the material contained within the vial of "Gap junction alpha-5 protein (Gja5), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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