Growth hormone-releasing hormone receptor (Ghrhr) Recombinant Protein | Ghrhr recombinant protein
Recombinant Mouse Growth hormone-releasing hormone receptor (Ghrhr)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family.
Protein type: Membrane protein, multi-pass; Cell development/differentiation; GPCR, family 2; Membrane protein, integral; Receptor, GPCR
Cellular Component: cell surface; cytoplasm; integral to membrane; membrane; nuclear inner membrane; nuclear matrix; nuclear outer membrane; plasma membrane; sarcolemma; secretory granule
Molecular Function: G-protein coupled receptor activity; growth factor binding; growth hormone-releasing hormone receptor activity; peptide hormone binding; protein binding; signal transducer activity; transmembrane receptor activity
Biological Process: adenohypophysis development; adenylate cyclase activation; cAMP-mediated signaling; cell maturation; cell surface receptor linked signal transduction; cellular response to insulin stimulus; determination of adult life span; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; growth hormone secretion; hormone metabolic process; lactation; mammary gland development; positive regulation of cAMP biosynthetic process; positive regulation of cAMP metabolic process; positive regulation of cell proliferation; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of growth hormone secretion; positive regulation of hormone secretion; positive regulation of multicellular organism growth; regulation of insulin-like growth factor receptor signaling pathway; regulation of protein metabolic process; regulation of steroid hormone receptor signaling pathway; response to estrogen stimulus; response to glucocorticoid stimulus; response to insulin stimulus; signal transduction; somatotropin secreting cell development; water homeostasis
Research Articles on Ghrhr
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Product Notes
The Ghrhr ghrhr (Catalog #AAA7015640) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 23-423aa; Full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Ghrhr ghrhr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: HLHLECDFIT QLRDDELACL QAAEGTNNTS LGCPGTWDGL LCWPPTGSGQ WVSLPCPEFF SHFGSDTGFV KRDCTITGWS NPFPPYPVAC PVPLELLTKE KSYFSTVKII YTTGHSISIV ALCVAIAILV ALRRLHCPRN YIHTQLFATF ILKASAVFLK DAAIFQGDST DHCSMSTVLC KVSVAISHLA TMTNFSWLLA EAVYLSCLLA STSPRSKPAF WWLVLAGWGL PVLCTGTWVG CKLAFEDTEC WDLDNSSPCW WIIKGPIVLS VGVNFGLFLN IICILLRKLE PAQGGLHTRA QYWRLSKSTL LLIPLFGIHY IIFNFLPDSA GLDIRVPLEL GLGSFQGFIV AVLYCFLNQE VRTEISRKWY GHDPELLPAR RTCTEWTTPP RSRLKVLTSE C. It is sometimes possible for the material contained within the vial of "Growth hormone-releasing hormone receptor (Ghrhr), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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