Uncharacterized protein yybT (yybT) Recombinant Protein | yybT recombinant protein
Recombinant Bacillus subtilis Uncharacterized protein yybT (yybT), partial
NCBI and Uniprot Product Information
Uniprot Description
Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP) and to a much lesser extent against cyclic-di-GMP (c-di-GMP) in the DHH/DHHA1 domains (PubMed:19901023, PubMed:21257773). Also has ATPase activity, probably via the GGDEF domain (PubMed:19901023, PubMed:21257773). Overexpression leads to increased sensitivity to methyl methanesulfonate (MMS) and H2O2 (PubMed:25616256). Overexpression leads to extreme sensitivity to the beta-lactam antibiotic cefuroxime (CEF), probably dependent on PDE activity (PubMed:22211522). May monitor cellular heme or NO levels (PubMed:21257773). In B.subtilis c-di-AMP is a second messenger that mediates growth, DNA repair and cell wall homeostasis; it is toxic when present in excess (PubMed:26240071).
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Product Notes
The yybT gdpp (Catalog #AAA1184477) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 173-301;GGDEF domain. The amino acid sequence is listed below: ERTVLAYIFL DNYDDVTQGL DDQTRSTMNS QVTSLLNAWA QEYGIFLKRT SSERFIAVLN EHILTELENS KFSILDEVRE KTSFDGVALT LSVGVGASVS SLKELGDLAQ SSLDLALGRG GDQVAIKLP . It is sometimes possible for the material contained within the vial of "Uncharacterized protein yybT (yybT), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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