Growth Dfferentiation Factor 11/GDF-11/BMP-11 Recombinant Protein | GDF-11/BMP-11 recombinant protein

Recombinant Human Growth Dfferentiation Factor 11/GDF-11/BMP-11 Protein

Cat. Num. AAA2552738

• Gene Names: GDF11; BMP11; BMP-11
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Growth Dfferentiation Factor 11/GDF-11/BMP-11; Recombinant Human Growth Dfferentiation Factor 11/GDF-11/BMP-11 Protein; Growth/differentiation factor 11; GDF-11; Bone morphogenetic protein 11; BMP-11; GDF-11/BMP-11 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
• Sequence Positions: Asn299-Ser407
• Sequence Length: 407

• Species: Human
• Endotoxin: < 1.0 EU per ug as determined by the LAL method.
• Reconstitution: It is recommended that sterile water (1mL) be added to the vial to prepare a stock solution of 0.5mg/mL. Concentration is measured by UV-Vis.
• Preparation and Storage: Storage: Lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; ; Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

SDS-PAGE

Related Product Information for GDF-11/BMP-11 recombinant protein

Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.

NCBI and Uniprot Product Information

• NCBI GI #: 5031613
• NCBI GeneID: 10220
• NCBI Accession #: NP_005802.1
• NCBI GenBank Nucleotide #: NM_005811.4
• UniProt Accession #: O95390; Q9UID1; Q9UID2
• Molecular Weight: Molecular Mass: 12.6 kDa; Actual Protein Molecular Mass: 14 kDa
• NCBI Official Full Name: growth/differentiation factor 11 preproprotein
• NCBI Official Synonym Full Names: growth differentiation factor 11
• NCBI Official Symbol: GDF11
• NCBI Official Synonym Symbols: BMP11; BMP-11
• NCBI Protein Information: growth/differentiation factor 11
• UniProt Protein Name: Growth/differentiation factor 11
• UniProt Gene Name: GDF11
• UniProt Synonym Gene Names: BMP111 PublicationManual assertion based on opinion iniRef.1; GDF-11; BMP-11

NCBI Description

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]

Uniprot Description

Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).