Fish glucokinase (hexokinase 4) ELISA Kit | GCK elisa kit
Fish Glucokinase, GCK ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
GK: a glycolytic enzyme that catalyzes glucose metabolism in the liver and pancreatic beta cells. Acts as a ""glucose sensor"" in beta cells. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. Glucokinase traps glucose inside the cell by catalyzing its phosphorylation to produce glucose-6-phosphate. Has a lower affinity for glucose than the three other isozymes of hexokinase, allowing other organs such as the brain and muscles to have first call on glucose when its supply is limited. Unlike other hexokinases, glucokinase is not inhibited by glucose-6-phosphate. Glucokinase is found in the outer membrane compartment of mitochondria. May bind VDAC, suppressing mitochondrial function. Glucokinase transcription is induced by insulin, perhaps via the activation of Stat 5B. Mutant glucokinase causes a rare form of diabetes and may also play a role in type 2 diabetes. Three splice variant isoforms of human glucokinase have been described.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.1.2; Carbohydrate Metabolism - galactose; Kinase, other; Mitochondrial; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - amino sugar and nucleotide sugar
Cellular Component: nucleoplasm; mitochondrion; cell; cytoplasm; actin filament; cell cortex; basal cortex; nucleus; cytosol; secretory granule
Molecular Function: transferase activity; hexokinase activity; protein binding; magnesium ion binding; nucleotide binding; kinase activity; phosphotransferase activity, alcohol group as acceptor; ADP binding; glucokinase activity; protein phosphatase binding; ATP binding; glucose binding
Biological Process: glucose 6-phosphate metabolic process; positive regulation of glycogen biosynthetic process; lipid homeostasis; glucose homeostasis; NADP metabolic process; cellular response to glucose starvation; detection of glucose; elevation of cytosolic calcium ion concentration; negative regulation of gluconeogenesis; second-messenger-mediated signaling; glycogen biosynthetic process; glycolysis; regulation of potassium ion transport; glucose metabolic process; positive regulation of insulin secretion; fructose 2,6-bisphosphate metabolic process; cellular response to insulin stimulus; carbohydrate phosphorylation; carbohydrate metabolic process; positive regulation of glycolysis; negative regulation of epinephrine secretion; cell glucose homeostasis; phosphorylation; regulation of insulin secretion; positive regulation of phosphorylation
Research Articles on GCK
Similar Products
Product Notes
The Fish GCK gck (Catalog #AAA9310876) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9310876 ELISA Kit recognizes Fish GCK. It is sometimes possible for the material contained within the vial of "glucokinase (hexokinase 4), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
