GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) Recombinant Protein | GAPVD1 recombinant protein

Recombinant Bovine GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1); Recombinant Bovine GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1); partial; GAPVD1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,413

• Species: Bovine
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 156523152
• NCBI GeneID: 539646
• NCBI Accession #: NP_001095990.1
• NCBI GenBank Nucleotide #: NM_001102520.1
• UniProt Accession #: A5D794
• Molecular Weight: 157,375 Da
• NCBI Official Full Name: GTPase-activating protein and VPS9 domain-containing protein 1
• NCBI Official Synonym Full Names: GTPase activating protein and VPS9 domains 1
• NCBI Official Symbol: GAPVD1
• NCBI Protein Information: GTPase-activating protein and VPS9 domain-containing protein 1
• UniProt Protein Name: GTPase-activating protein and VPS9 domain-containing protein 1
• Protein Family: GTPase-activating protein and VPS9 domain-containing protein
• UniProt Gene Name: GAPVD1

Uniprot Description

Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras ().