GALK1/Galactokinase/Galactose Recombinant Protein | GALK1 recombinant protein

Recombinant Human GALK1/Galactokinase/Galactose Protein (C-His)

Cat. Num. AAA2557282

• Gene Names: GALK1; GK1; GALK; HEL-S-19
• Purity: >85% as determined by reducing SDS-PAGE.
• Synonyms: GALK1/Galactokinase/Galactose; Recombinant Human GALK1/Galactokinase/Galactose Protein (C-His); Galactokinase; Galactose Kinase; GALK1; GALK; GALK1 recombinant protein

• Host: E Coli
• Purity/Purification: >85% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
• Sequence: Met1-Leu392
• Sequence Length: 392

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months. Please minimize freeze-thaw cycles.

Related Product Information for GALK1 recombinant protein

Protein Construction: Recombinant Human GALK1 is produced by our E Coli expression system and the target gene encoding Met1-Leu392 is expressed with a 6His tag at the C-terminus.

Background: Galactokinase belongs to the GHMP kinase family and GalK subfamily. Galactokinase is more important to the galactose metabolism pathway. It modifies galactose to create a similar molecule called Galactose-1-Phosphate.Thus, a series of additional steps converts Galactose-1-Phosphate to another simple sugar Glucose, which is the main energy source for most cells. Galactokinase deficiency results in Galactosemia II, an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of Galactitol in the lenses.

NCBI and Uniprot Product Information

• NCBI GI #: 4503895
• NCBI GeneID: 2584
• NCBI Accession #: NP_000145.1
• NCBI GenBank Nucleotide #: NP_000145.1
• UniProt Accession #: P51570
• Molecular Weight: Molecular Mass: 43.3kDa; Actual Protein Molecular Mass: 45kDa
• NCBI Official Full Name: galactokinase
• NCBI Official Synonym Full Names: galactokinase 1
• NCBI Official Symbol: GALK1
• NCBI Official Synonym Symbols: GK1; GALK; HEL-S-19
• NCBI Protein Information: galactokinase
• UniProt Protein Name: Galactokinase
• UniProt Gene Name: GALK1
• UniProt Synonym Gene Names: GALK
• UniProt Entry Name: GALK1_HUMAN

NCBI Description

Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. [provided by RefSeq, Jul 2008]

Uniprot Description

GALK1: Major enzyme for galactose metabolism. Defects in GALK1 are the cause of galactosemia II (GALCT2). Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses. Belongs to the GHMP kinase family. GalK subfamily.

Protein type: Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Kinase, other; EC 2.7.1.6

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: membrane; cytoplasm; cytosol

Molecular Function: galactokinase activity; galactose binding; ATP binding

Biological Process: galactose catabolic process; carbohydrate phosphorylation; carbohydrate metabolic process; galactitol metabolic process; galactose metabolic process; pathogenesis

Disease: Galactokinase Deficiency