Human growth arrest and DNA-damage-inducible, gamma interacting protein 1 ELISA Kit | GADD45GIP1 elisa kit
Human Growth arrest and DNA damage-inducible proteins-interacting protein 1, GADD45GIP1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
Uniprot Description
GADD45GIP1: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Down-regulated by p53/TP53 in apoptotic cells. Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.
Protein type: Nuclear receptor co-regulator; Cell cycle regulation
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: mitochondrion; mitochondrial matrix; nucleus
Molecular Function: protein binding
Biological Process: viral reproduction; mitochondrial translation; organelle organization and biogenesis; cell cycle
Research Articles on GADD45GIP1
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Product Notes
The Human GADD45GIP1 gadd45gip1 (Catalog #AAA9317986) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317986 ELISA Kit recognizes Human GADD45GIP1. It is sometimes possible for the material contained within the vial of "growth arrest and DNA-damage-inducible, gamma interacting protein 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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