Porcine Growth Arrest and DNA Damage Inducible Protein Alpha ELISA Kit | GADD45alpha elisa kit
Porcine Growth Arrest and DNA Damage Inducible Protein Alpha ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
Uniprot Description
GADD45A: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Interacts with MAPK14. Interacts with GADD45GIP1. Interacts with PCNA. By UV irradiation, X-rays, growth arrest and alkylating agents. The induction is mediate by some kinase(s) other than PKC. Belongs to the GADD45 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage; Nuclear receptor co-regulator; Apoptosis; Cell cycle regulation
Chromosomal Location of Human Ortholog: 1p31.2
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: apoptosis; positive regulation of apoptosis; centrosome cycle; activation of MAPKKK activity; DNA damage response, signal transduction; positive regulation of JNK cascade; negative regulation of protein kinase activity; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; DNA repair
Research Articles on GADD45alpha
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Product Notes
The Porcine GADD45alpha gadd45a (Catalog #AAA062386) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA062386 ELISA Kit recognizes Porcine GADD45alpha. It is sometimes possible for the material contained within the vial of "Growth Arrest and DNA Damage Inducible Protein Alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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