GABA(A) Receptor-Associated Protein Like 1 Recombinant Protein | GABARAPL1 recombinant protein
Recombinant Human GABA(A) Receptor-Associated Protein Like 1
Sterile Filtered colorless solution.
Introduction: GABARAPL1 [Gamma-aminobutyric acid (GABA) receptor-associated protein-like 1] is a member of the MAP1 LC3 family. GABARAPL1 increases cell surface expression of kappa type opioid receptor through facilitating anterograde intracellular trafficking of the receptor.
NCBI and Uniprot Product Information
Uniprot Description
GABARAPL1: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Belongs to the MAP1 LC3 family. Interacts with GABRG2 and beta-tubulin. Interacts with KOR-1.
Protein type: Vesicle; Autophagy; Ubiquitin-like modifier; Adaptor/scaffold; Microtubule-binding
Chromosomal Location of Human Ortholog: 12p13.2
Cellular Component: dendrite cytoplasm; Golgi apparatus; microtubule; extrinsic to membrane; cytoplasmic vesicle membrane; mitochondrion; endoplasmic reticulum; autophagic vacuole; intracellular; cytosol
Molecular Function: protein binding; Tat protein binding; microtubule binding; beta-tubulin binding; GABA receptor binding
Biological Process: mitochondrion degradation; autophagic vacuole formation
Research Articles on GABARAPL1
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Product Notes
The GABARAPL1 gabarapl1 (Catalog #AAA144205) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK. It is sometimes possible for the material contained within the vial of "GABA(A) Receptor-Associated Protein Like 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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