Human GABA (A) receptor-associated protein like 1 ELISA Kit | GABARAPL1 elisa kit
Human Gamma-aminobutyric acid receptor-associated protein-like 1, GABARAPL1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
GABARAPL1: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Belongs to the MAP1 LC3 family. Interacts with GABRG2 and beta-tubulin. Interacts with KOR-1.
Protein type: Microtubule-binding; Ubiquitin-like modifier; Vesicle; Autophagy; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 12p13.2
Cellular Component: dendrite cytoplasm; Golgi apparatus; microtubule; extrinsic to membrane; cytoplasmic vesicle membrane; mitochondrion; endoplasmic reticulum; autophagic vacuole; intracellular; cytosol
Molecular Function: protein binding; Tat protein binding; microtubule binding; GABA receptor binding; beta-tubulin binding
Biological Process: mitochondrion degradation; autophagic vacuole formation
Research Articles on GABARAPL1
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Product Notes
The Human GABARAPL1 gabarapl1 (Catalog #AAA9336351) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336351 ELISA Kit recognizes Human GABARAPL1. It is sometimes possible for the material contained within the vial of "GABA (A) receptor-associated protein like 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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