GABARAP recombinant protein

GABARAP, 1-117aa, Human, His tag, E Coli

Cat. Num. AAA203430

• Gene Names: GABARAP; MM46; ATG8A; GABARAP-a
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: GABARAP; 1-117aa; Human; His tag; E Coli; Gamma-aminobutyric acid receptor-associated protein; MM46; Gamma-aminobutyric acid receptor-associated protein FLC 3B; FLC3B; FLJ25768; GABA (A) receptor associated protein; Gamma aminobutyric acid receptor associated protein; MGC120154; MGC120155; MM 46; MM46.; GABARAP recombinant protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol 0.2M NaCl
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL
• Sequence Length: 117

• Applicable Applications for GABARAP recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for GABARAP recombinant protein

GABARAP, also known as gamma-aminobutyric acid receptor-associated protein, is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Recombinant GABARAP protein was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for GABARAP recombinant protein

Neuroscience

References

Stangler T., et al. (2002) J Biol Chem. 277 (16):13363-6.

NCBI and Uniprot Product Information

• NCBI GI #: 6005764
• NCBI GeneID: 11337
• NCBI Accession #: NP_009209
• NCBI GenBank Nucleotide #: NM_007278.1
• UniProt Accession #: O95166
• Molecular Weight: 16 kDa (137aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: gamma-aminobutyric acid receptor-associated protein
• NCBI Official Synonym Full Names: GABA type A receptor-associated protein
• NCBI Official Symbol: GABARAP
• NCBI Official Synonym Symbols: MM46; ATG8A; GABARAP-a
• NCBI Protein Information: gamma-aminobutyric acid receptor-associated protein
• UniProt Protein Name: Gamma-aminobutyric acid receptor-associated protein
• Protein Family: Gamma-aminobutyric acid receptor-associated protein
• UniProt Gene Name: GABARAP
• UniProt Synonym Gene Names: FLC3B

NCBI Description

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

Uniprot Description

Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.