Human glucose-6-phosphatase, catalytic, 2 ELISA Kit | G6PC2 elisa kit
Human Glucose-6-phosphatase 2, G6PC2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
G6PC2: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis. Belongs to the glucose-6-phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; EC 3.1.3.9; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - galactose; Transporter, SLC family; Phosphatase (non-protein); Endoplasmic reticulum; Membrane protein, integral; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Transporter
Chromosomal Location of Human Ortholog: 2q24.3
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: glucose-6-phosphatase activity
Biological Process: dephosphorylation; hexose transport; carbohydrate metabolic process; pathogenesis; glucose transport; glucose homeostasis; transmembrane transport; regulation of insulin secretion; gluconeogenesis
Disease: Fasting Plasma Glucose Level Quantitative Trait Locus 1
Research Articles on G6PC2
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Product Notes
The Human G6PC2 g6pc2 (Catalog #AAA9332546) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332546 ELISA Kit recognizes Human G6PC2. It is sometimes possible for the material contained within the vial of "glucose-6-phosphatase, catalytic, 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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