Transmembrane GTPase fzo (fzo) Recombinant Protein | fzo recombinant protein
Recombinant Drosophila melanogaster Transmembrane GTPase fzo (fzo)
NCBI and Uniprot Product Information
Uniprot Description
Function: Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis. In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Essential for fertility. Ref.1
Catalytic activity: GTP + H2O = GDP + phosphate.
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein Ref.1.
Tissue specificity: Specifically expressed in male germ cells, in spermatocytes and early spermatids. Not expressed in other tissues. Ref.1 Ref.5
Developmental stage: Associated with mitochondria in spermatids during a narrow developmental window. Mitochondria align on the spindle equator throughout meiotic divisions, but it is not expressed on mitochondria until the last of meiosis II. In postmeiotic haploid spermatids, it is associated with aggregating mitochondria and highly expressed on onion stage Nebenkerns. Expressed at lower levels associated with early elongation stage mitochondrial derivatives. Not detected on more elongated mitochondria.
Sequence similarities: Belongs to the mitofusin family.
Research Articles on fzo
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Product Notes
The fzo fzo (Catalog #AAA1116185) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-718. The amino acid sequence is listed below: MAESDSGEST SSVSSFISSS SSSRLSEFVD AKTELQDIYH DLSNYLSNFL TILEETVLLK DRQMLEHLCA FSSRVEAIAK VLSRDRMKVA FFGRTSNGKS AVINALLHEK ILPSAMGHTT SCFCQVQANG SNETEHVKVE QEDEHMELSA LSQLASAHSP GALKPSTLLQ VNMAKNRCSI LDYDVVLMDT PGVDVTAQLD DCLDSYCMDA DVFILVLNAE STVSRVERQF FKDVASKLSR PNLFILNNRW DKASSLEPEM EQKVKDQHME RCVNLLVDEL GVYSTAQEAW ERIYHVSALE ALHIRNGQIT NPSGQTQQRY QEFLRFENDF SNCLAVSALK TKFGPHLLSA QKILNQLKST LICPFIEKVS RLIDENKERR ANLNAEIEDW LILMQEDREA LQYCFEELTE MTQRVGRCVL NDQIKTLIPS SVLSFSQPFH PEFPAQIGQY QRSLCAHLDK LLEDRVLQCL SIPLQRKILD IEKEIGLPIA ENSCDWQLIY GLDCQSYMSD FQPDLRFRFS LGFTALWHRL EGNLPLHASP FRIQKLQNGH KKCSPLPPLV NGNHWQMLES LVKSKGSLGT VLLSAMAIRS FNWPIVLILG GLVGSFYIYE YAAWTTAAQE RSFKSQYARL LQQRLRSDVQ QTVSGFELQL RQHLATVRNC WEAQSNETLN DLNVRTAELT KQIQSMEVLQ LSLKKFRDKG QLLASRLGDF QETYLTKS. It is sometimes possible for the material contained within the vial of "Transmembrane GTPase fzo (fzo), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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