Frizzled-6 (FZD6) Recombinant Protein | FZD6 recombinant protein
Recombinant Human Frizzled-6 (FZD6)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
Uniprot Description
FZD6: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney. Belongs to the G-protein coupled receptor Fz/Smo family.
Protein type: GPCR, Fz/Smo family; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 8q22.3-q23.1
Cellular Component: apical plasma membrane; apicolateral plasma membrane; cell surface; cytoplasmic vesicle membrane; integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; protein binding; ubiquitin protein ligase binding; Wnt receptor activity; Wnt-protein binding
Biological Process: cell proliferation in midbrain; establishment of planar polarity; G-protein coupled receptor protein signaling pathway; hair follicle development; inner ear morphogenesis; negative regulation of transcription factor activity; neural tube closure; platelet activation; Wnt receptor signaling pathway, calcium modulating pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Disease: Nail Disorder, Nonsyndromic Congenital, 10
Research Articles on FZD6
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Product Notes
The FZD6 fzd6 (Catalog #AAA7015414) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 19-706aa; Full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the FZD6 fzd6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: HSLFTCEPIT VPRCMKMAYN MTFFPNLMGH YDQSIAAVEM EHFLPLANLE CSPNIETFLC KAFVPTCIEQ IHVVPPCRKL CEKVYSDCKK LIDTFGIRWP EELECDRLQY CDETVPVTFD PHTEFLGPQK KTEQVQRDIG FWCPRHLKTS GGQGYKFLGI DQCAPPCPNM YFKSDELEFA KSFIGTVSIF CLCATLFTFL TFLIDVRRFR YPERPIIYYS VCYSIVSLMY FIGFLLGDST ACNKADEKLE LGDTVVLGSQ NKACTVLFML LYFFTMAGTV WWVILTITWF LAAGRKWSCE AIEQKAVWFH AVAWGTPGFL TVMLLAMNKV EGDNISGVCF VGLYDLDASR YFVLLPLCLC VFVGLSLLLA GIISLNHVRQ VIQHDGRNQE KLKKFMIRIG VFSGLYLVPL VTLLGCYVYE QVNRITWEIT WVSDHCRQYH IPCPYQAKAK ARPELALFMI KYLMTLIVGI SAVFWVGSKK TCTEWAGFFK RNRKRDPISE SRRVLQESCE FFLKHNSKVK HKKKHYKPSS HKLKVISKSM GTSTGATANH GTSAVAITSH DYLGQETLTE IQTSPETSMR EVKADGASTP RLREQDCGEP ASPAASISRL SGEQVDGKGQ AGSVSESARS EGRISPKSDI TDTGLAQSNN LQVPSSSEPS SLKGSTSLLV HPVSGVRKEQ GGGCHSDT. It is sometimes possible for the material contained within the vial of "Frizzled-6 (FZD6), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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