Mouse frizzled homolog 5 (Drosophila) ELISA Kit | FZD5 elisa kit
Mouse Frizzled-5, FZD5 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
FZD5: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family.
Protein type: GPCR, Fz/Smo family; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Cellular Component: Golgi apparatus; tight junction; cell surface; membrane; perinuclear region of cytoplasm; early endosome; integral to membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; signal transducer activity; Wnt receptor activity; protein binding; transmembrane receptor activity; ubiquitin protein ligase binding; protein kinase binding
Biological Process: positive regulation of JNK activity; post-embryonic camera-type eye development; Wnt receptor signaling pathway; multicellular organismal development; embryonic axis specification; cell maturation; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; signal transduction; embryonic camera-type eye development; negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; vasculature development; determination of anterior/posterior axis, embryo; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; cell differentiation; Spemann organizer formation
Research Articles on FZD5
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Product Notes
The Mouse FZD5 fzd5 (Catalog #AAA9333419) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333419 ELISA Kit recognizes Mouse FZD5. It is sometimes possible for the material contained within the vial of "frizzled homolog 5 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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