Ferritin Protein | FTL protein
Ferritin, Human Liver
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Human Ferritin is a globular protein found mainly in the liver, which can store about 4,500 iron ions in a hollow shell made of 24 identical subunits. Inside the human ferritin shell, iron ions form crystallites together with phosphate and hydroxide ions.
Human Serum ferritin levels are measured in patients as part of the iron studies workup for anemia and for restless leg syndrome. Human ferritin levels have a direct correlation with the total amount of iron stored in the body. Human Ferritin levels are also indicative of the erosion of iron stores during pregnancy.
NCBI and Uniprot Product Information
Uniprot Description
FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: ferritin complex; membrane; cytosol
Molecular Function: identical protein binding; protein binding; ferric iron binding; iron ion binding
Biological Process: receptor-mediated endocytosis; iron ion homeostasis; cellular iron ion homeostasis; post-Golgi vesicle-mediated transport; transmembrane transport; iron ion transport
Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3
Research Articles on FTL
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Product Notes
The FTL ftl (Catalog #AAA173074) is a Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ferritin, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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