Mouse Follicle-stimulating hormone receptor ELISA Kit | Fshr elisa kit
Mouse Follicle-stimulating hormone receptor ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: cell surface; endosome; integral to membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: follicle-stimulating hormone receptor activity; G-protein coupled receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein-hormone receptor activity; signal transducer activity
Biological Process: adenylate cyclase activation; cellular water homeostasis; follicle-stimulating hormone signaling pathway; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); hormone-mediated signaling; locomotory behavior; negative regulation of bone resorption; neurite development; ovarian follicle development; ovulation cycle process; positive regulation of estrogen receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; primary ovarian follicle growth; regulation of chromosome organization and biogenesis; regulation of estrogen receptor signaling pathway; regulation of hormone metabolic process; regulation of MAPKKK cascade; regulation of osteoclast differentiation; regulation of protein amino acid phosphorylation; regulation of systemic arterial blood pressure; Sertoli cell development; Sertoli cell proliferation; signal transduction; sperm chromatin condensation; spermatid development; spermatogenesis; spermatogenesis, exchange of chromosomal proteins; transcytosis; uterus development
