Forkhead box protein O (foxo) Recombinant Protein | foxo recombinant protein

Recombinant Drosophila mojavensis Forkhead box protein O (foxo), partial

• Gene Names: DmojGI21984; dmoj_GLEANR_7239; foxo; GI21984
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Forkhead box protein O (foxo); Recombinant Drosophila mojavensis Forkhead box protein O (foxo); partial; foxo recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 563

• Species: Drosophila mojavensis (Fruit fly)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 968060690
• NCBI GeneID: 6575413
• NCBI Accession #: XP_002001423.2
• NCBI GenBank Nucleotide #: XM_002001387.2
• UniProt Accession #: B4KBF6
• Molecular Weight: 61,986 Da
• NCBI Official Full Name: uncharacterized protein Dmoj_GI21984, isoform C
• NCBI Official Symbol: DmojGI21984
• NCBI Official Synonym Symbols: dmoj_GLEANR_7239; foxo; GI21984
• NCBI Protein Information: GI21984 gene product from transcript GI21984-RB
• UniProt Protein Name: Forkhead box protein O
• Protein Family: Forkhead box protein
• UniProt Gene Name: foxo

Uniprot Description

Transcription factor involved in the regulation of the insulin signaling pathway. Consistently activates both the downstream target Thord4EBP and the feedback control target InR. Involved in negative regulation of the cell cycle, modulating cell growth and proliferation. In response to cellular stresses, such as nutrient deprivation or increased levels of reactive oxygen species, foxo is activated and inhibits growth through the action of target genes such as Thor. Foxo activated in the adult fat body can regulate lifespan in adults; an insulin peptide itself may function as one secondary messenger of insulin-regulated aging. Also regulates Lip4, homolog of human acid lipases, thereby acting as a key modulator of lipid metabolism by insulin signaling and integrates insulin responses to glucose and lipid homeostasis ().