Fibronectin Type III Domain Containing 5 Active Protein | FNDC5 active protein
Recombinant Human Fibronectin Type III Domain Containing 5, Yeast
Gene Names
FNDC5; FRCP2; irisin
Purity
Greater than 98.0% as determined by SDS-PAGE.
Synonyms
Fibronectin Type III Domain Containing 5; Recombinant Human Fibronectin Type III Domain Containing 5; Yeast; FNDC5 Human; Fibronectin Type III Domain Containing 5 Human Recombinant; Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; Irisin; FRCP2; FNDC5; FNDC5 Yeast; FNDC5 active protein
Purity/Purification
Greater than 98.0% as determined by SDS-PAGE.
Form/Format
The FNDC5 was lyophilized from 0.45 um filtered solution in PBS.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
S_P__S__A__P__V__N__V__T__V__R__H__L__K__A__N__S__A__V__V__S_W__D__V__L__E__D__E__V__V__I__G__F__A__I__S__Q__Q__K__K__D _V__R__M__L__R__F__I__Q__E__V__N__T__T__T__R__S__C__A__L__W__ D__L__E__E__D__T__E__Y__I__V__H__V__Q__A__I__S__I__Q__G__Q_S__P__A__S__E__P__V__L__F__K__T__P__R__E__A__E__K__M__A__S_ K__N__K__D__E__V__T__M__K__E
Sequence Length
181
Solubility
It is recommended to reconstitute the lyophilized Fibronectin Type III Domain Containing 5 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The biological activity of recombinant human irisin was measured by the ability to induce UCP-1 expression of adipocytes. The specific activity is 10ng/ml.
Preparation and Storage
Lyophilized Fibronectin Type III Domain Containing 5 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FNDC5 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
Related Product Information for FNDC5 active protein
Description: Fibronectin Type III Domain Containing 5 Human Recombinant produced in yeast is a glycosylated, polypeptide chain containing 110 amino acids and having a molecular mass of 20-25 kDa.FNDC5 is purified by proprietary chromatographic techniques.
Introduction: Fibronectin Type III Domain Containing 5 (Irisin) is a newly discovered hormone, secreted into circulation by muscle, which acts on white adipocytes and promotes WAT œbrowning. r-Irisin can reduce body weight and cause induction of brown adipocyte in vivo, including a capacity for thermogenic energy expenditure mediated by uncoupling protein 1 (UCP-1). Irisin mature protein is comprised of 110 amino acid residues and two potential glycosylation sites. High levels of Irisin can be found in the heart whereas Very low expression is found in the colon, pancreas and spleen, if any.
Introduction: Fibronectin Type III Domain Containing 5 (Irisin) is a newly discovered hormone, secreted into circulation by muscle, which acts on white adipocytes and promotes WAT œbrowning. r-Irisin can reduce body weight and cause induction of brown adipocyte in vivo, including a capacity for thermogenic energy expenditure mediated by uncoupling protein 1 (UCP-1). Irisin mature protein is comprised of 110 amino acid residues and two potential glycosylation sites. High levels of Irisin can be found in the heart whereas Very low expression is found in the colon, pancreas and spleen, if any.
Product Categories/Family for FNDC5 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
15,527 Da
NCBI Official Full Name
fibronectin type III domain-containing protein 5 isoform 3 preproprotein
NCBI Official Synonym Full Names
fibronectin type III domain containing 5
NCBI Official Symbol
FNDC5
NCBI Official Synonym Symbols
FRCP2; irisin
NCBI Protein Information
fibronectin type III domain-containing protein 5; fibronectin type III repeat-containing protein 2
UniProt Protein Name
Fibronectin type III domain-containing protein 5
Protein Family
UniProt Gene Name
FNDC5
UniProt Synonym Gene Names
FRCP2
UniProt Entry Name
FNDC5_HUMAN
NCBI Description
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Description
FNDC5: Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p35.1
Cellular Component: peroxisomal membrane; endoplasmic reticulum; integral to membrane; plasma membrane; extracellular region
Molecular Function: hormone activity
Biological Process: response to muscle activity
Research Articles on FNDC5
Similar Products
Product Notes
The FNDC5 fndc5 (Catalog #AAA145713) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: S_P__S__A_ _P__V__N__ V__T__V__R __H__L__K_ _A__N__S__ A__V__V__S _W__D__V__ L__E__D__E __V__V__I_ _G__F__A__ I__S__Q__Q __K__K__D _V__R__M__ L__R__F__I __Q__E__V_ _N__T__T__ T__R__S__C __A__L__W_ _ D__L__E__E __D__T__E_ _Y__I__V__ H__V__Q__A __I__S__I_ _Q__G__Q_S __P__A__S_ _E__P__V__ L__F__K__T __P__R__E_ _A__E__K__ M__A__S_ K__N__K__D __E__V__T_ _M__K__E. It is sometimes possible for the material contained within the vial of "Fibronectin Type III Domain Containing 5, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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