Dimethylaniline monooxygenase [N-oxide-forming] 4 (FMO4) Recombinant Protein | FMO4 recombinant protein
Recombinant Human Dimethylaniline monooxygenase [N-oxide-forming] 4 (FMO4)
NCBI and Uniprot Product Information
NCBI Description
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jul 2008]
Uniprot Description
FMO4: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Belongs to the FMO family.
Protein type: Membrane protein, integral; EC 1.14.13.8; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450
Chromosomal Location of Human Ortholog: 1q24.3
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: FAD binding; NADP binding; flavin-containing monooxygenase activity
Biological Process: drug catabolic process
Research Articles on FMO4
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Product Notes
The FMO4 fmo4 (Catalog #AAA955892) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-558. The amino acid sequence is listed below: AKKVAVIGAG VSGLSSIKCC VDEDLEPTCF ERSDDIGGLW KFTESSKDGM TRVYKSLVTN VCKEMSCYSD FPFHEDYPNF MNHEKFWDYL QEFAEHFDLL KYIQFKTTVC SITKRPDFSE TGQWDVVTET EGKQNRAVFD AVMVCTGHFL NPHLPLEAFP GIHKFKGQIL HSQEYKIPEG FQGKRVLVIG LGNTGGDIAV ELSRTAAQVL LSTRTGTWVL GRSSDWGYPY NMMVTRRCCS FIAQVLPSRF LNWIQERKLN KRFNHEDYGL SITKGKKAKF IVNDELPNCI LCGAITMKTS VIEFTETSAV FEDGTVEENI DVVIFTTGYT FSFPFFEEPL KSLCTKKIFL YKQVFPLNLE RATLAIIGLI GLKGSILSGT ELQARWVTRV FKGLCKIPPS QKLMMEATEK EQLIKRGVFK DTSKDKFDYI AYMDDIAACI GTKPSIPLLF LKDPRLAWEV FFGPCTPYQY RLMGPGKWDG ARNAILTQWD RTLKPLKTRI VPDSSKPASM SHYLKAWGAP VLLASLLLIC KSSLFLKLVR DKLQDRMSPY LVSLWRG. It is sometimes possible for the material contained within the vial of "Dimethylaniline monooxygenase [N-oxide-forming] 4 (FMO4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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