FK506 Binding Protein 5 Recombinant Protein | FKBP5 recombinant protein

Recombinant Human FK506 Binding Protein 5

Cat. Num. AAA140848

• Gene Names: FKBP5; P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: FK506 Binding Protein 5; Recombinant Human FK506 Binding Protein 5; 54 KDa Progesterone Receptor-Associated Immunophilin; 51 KDa FK506-Binding Protein; Androgen-Regulated Protein 6; HSP90-Binding Immunophilin; FK506-Binding Protein 5; PPIase FKBP5; 51 KDa FKBP; FF1 Antigen; EC 5.2.1.8; Rotamase; FKBP-51; FKBP51; FKBP54; AIG6; P54; Peptidylprolyl Cis-Trans Isomerase; T-Cell FK506-Binding Protein; PPIASE; Ptg-10; FKBP-5; FKBP5.; FKBP5 recombinant protein

• Host: E coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: FKBP5 was filtered (0.4um) and lyophilized in 20mM Tris buffer and 50mM NaCl, pH 7.5.!!Solubility||
• Sequence: MKHHHHHHAS MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV.
• Sequence Length: 457

• Physical Appearance: Filtered White lyophilized (freeze-dried) powder.
• Solubility: It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Filter sterilize your culture media/working solutions containing this non-sterile FKBP5 before using in cell culture.
• Preparation and Storage: Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Related Product Information for FKBP5 recombinant protein

Introduction: FK506 Binding Protein 5 (FKBP5) belongs to the immunophilin protein family, which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP5 is a cis-trans prolyl isomerase, which binds to the immunosuppressants FK506 and rapamycin. FKBP5 is an immunophilin protein with PPIase and co-chaperone activities. FKBP5 is assumed to mediate calcineurin inhibition. FKBP5 is a component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). In addition, FKBP5 interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein.

Desription: FKBP5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Met1-Val457) containing 467 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 52.5kDa.

Product Categories/Family for FKBP5 recombinant protein

Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 83404904
• NCBI GeneID: 2289
• Molecular Weight: 30,032 Da
• NCBI Official Full Name: FK506 binding protein 5
• NCBI Official Synonym Full Names: FK506 binding protein 5
• NCBI Official Symbol: FKBP5
• NCBI Official Synonym Symbols: P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP5
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP5
• Protein Family: FK506-binding protein
• UniProt Gene Name: FKBP5
• UniProt Synonym Gene Names: AIG6; FKBP51; PPIase FKBP5; 51 kDa FKBP; FKBP-51; FKBP-5; p54
• UniProt Entry Name: FKBP5_HUMAN

Uniprot Description

FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin.

Protein type: Chaperone; EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: endoplasmic reticulum membrane; membrane; nucleoplasm

Molecular Function: heat shock protein binding; peptidyl-prolyl cis-trans isomerase activity; protein binding

Biological Process: protein folding

Disease: Major Depressive Disorder