FKBP5 / Peptidyl-Prolyl Cis-Trans Isomerase FKBP5 Recombinant Protein | FKBP5 recombinant protein

Human FKBP5 / Peptidyl-Prolyl Cis-Trans Isomerase FKBP5 Recombinant Protein

• Gene Names: FKBP5; P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: FKBP5 / Peptidyl-Prolyl Cis-Trans Isomerase FKBP5; Human FKBP5 / Peptidyl-Prolyl Cis-Trans Isomerase FKBP5 Recombinant Protein; Peptidyl-prolyl cis-trans isomerase FKBP5; PPIase FKBP5; 51 kDa FK506-binding protein; 51 kDa FKBP; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase; AIG6; FKBP51; FKBP5 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 457

• Applicable Applications for FKBP5 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
• Entry Function: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 2851536
• NCBI GeneID: 2289
• UniProt Accession #: Q13451
• NCBI Official Full Name: Peptidyl-prolyl cis-trans isomerase FKBP5
• NCBI Official Synonym Full Names: FKBP prolyl isomerase 5
• NCBI Official Symbol: FKBP5
• NCBI Official Synonym Symbols: P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP5
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP5
• Protein Family: FK506-binding protein
• UniProt Gene Name: FKBP5
• UniProt Synonym Gene Names: AIG6; FKBP51; PPIase FKBP5; 51 kDa FKBP; FKBP-51; FKBP-5; p54
• UniProt Entry Name: FKBP5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Uniprot Description

FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin.

Protein type: EC 5.2.1.8; Isomerase; Chaperone

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; heat shock protein binding

Biological Process: protein peptidyl-prolyl isomerization; protein folding

Disease: Major Depressive Disorder